The exact role of platelets in VEGF regulation has not been completely clarified so far: some authors evidenced, in retinal growth, an anti-angiogenic effect of platelets due to the removal of VEGF surplus during the phase of vascularization [14,27,28], while others showed low VEGF-A levels in correlation with low postnatal platelets counts and severe ROP development [29]. The gene discussed is VEGFA; the disease is retinopathy of prematurity.