Cytokeratin 19 fragment (CYFRA 21-1), carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCCA), and carbohydrate antigen 125 (CA125) are well established and the most commonly used blood/serum biomarkers for the detection of LC, used either as a single biomarker [33] or in panels of several combined biomarkers [34,35]. This evidence concerns the gene CEACAM5 and laryngotracheoesophageal cleft.