Based on the recent publication about best practice recommendations for the usage of IHC in lung cancer diagnostic, TTF-1 (Thyroid Transcription Factor 1) (for ADC) and p40 (for SQC) are designated as the best markers for the subtyping of NSCLC, especially when the 8G7G3/1 monoclonal antibody is used for TTF-1 detection. The gene discussed is TTF1; the disease is lung carcinoma.