Currently, clinical activity of multi-kinase inhibitor MGCD516 is being evaluated in NSCLCs and head and neck cancer populations with DDR2 mutations and/or other activating mutations (MET, NTRK2, NTRK3), rearrangements (MET, RET, AXL, NTRK1, or NTRK3), or amplifications (MET or KIT/PDGFRA/KDR) (NCT02219711). This evidence concerns the gene NTRK3 and head and neck cancer.