Similarly, in recessive inheritance model, ACE2-DI + II genotype (DD vs. DI + II) was strongly associated with increased COVID-19 mortality with OR 4.0 (95%) CI = (1.7769 to 9.0432), RR = 2.45 (1.4031 to 4.2927), p < 0.0008. Here, ACE2 is linked to COVID-19.