ACE2 and COVID-19: There is a strong association observed between ACE2–II genotype vs. ACE2-(DI + DD) genotype in dominant inheritance model and leads to increased COVID-19 severity with OR = 2.39 (95%) CI (1.21–4.35), RR = 1.37 (1.11–1.69), p < 0.010 (Table 4).