ACE2 and COVID-19: As can be seen in Table 6, our result indicated that in the codominant model, the ACE2-ID heterozygosity genotype (II vs. DI) was strongly associated with increased COVID-19 severity in subjects with age >40 with OR 6.0 (95%) CI = (1.41 to 25.38), RR = 4.12 (1.33 to 12.74), p < 0.014.