As the PPARγ ligand RGZ has been shown to interfere with this axis in other solid tumors [13,14,15,16], we evaluated whether the CXCL12/CXCR4 axis might contribute in mediating the ACC anti-cancer activity of RGZ [9,11,12,17] in different ACC cell lines. This evidence concerns the gene CXCL12 and adrenal cortex carcinoma.