Since CXCL12 production is stimulated by estradiol in ovarian and breast cancer [33] and mitotane’s effects have been described to be partially mediated by the activation of the estradiol receptors [34] also in ACC [27], mitotane-induced CXCL12 production in ACC might at least partially involve estrogen-like activity. Here, ESR1 is linked to adrenal cortex carcinoma.