APC and breast cancer: NEK2 co-expressed genes from the METABRIC and TCGA breast cancer datasets were analyzed by MetaCore and revealed that NEK2 co-expressed genes were involved in cell cycle process including “The metaphase checkpoint”, “Role of APC in cell cycle regulation”, “Chromosome condensation in prometaphase”, “Start of DNA replication in early S phase”, and “Spindle assembly and chromosome separation” in breast cancer development (Figure 8, Table S3 in Supplementary).