Although CYFRA 21-1 appears to be a sensitive biomarker for CK19 expression in HCCs with a predictive power of 0.81 [11,12], routine laboratory test of preoperative serum CYFRA 21-1 may be limited, as CK19 expression is only present in approximately 10–30% of HCC patients. This evidence concerns the gene KRT19 and hepatocellular carcinoma.