Evidence has also shown that STAT3 enables cross-talk of the JAK/STAT pathway with the other gp130/IL6ST-dependent pathways, contributing to cancer-promoting effects of the MAPK/MEK/ERK and PI3K/AKT signalling pathways, such as chemo-resistance and epithelial-mesenchymal transition (EMT) [90,91]. This evidence concerns the gene STAT3 and cancer.