In addition to NPAS3, four other proteins have so far been implicated as aggregating in major mental illness: Collapsin Response Mediator Protein 1 (CRMP1) [18], Disrupted in Schizophrenia 1 (DISC1) [6], dysbindin-1 [17] and Trio and F-actin Binding Protein (TRIOBP) [19], all of which have previously detected as insoluble in the brains of schizophrenia patients. This evidence concerns the gene TRIO and schizophrenia.