NPAS3 and major depressive disorder: The presence of insoluble NPAS3 was present across all diagnoses and showed no specificity to any diagnoses (Figure 1c, ANOVA, p = 0.24, F < Fcrit, df = 3, relative levels of NPAS3 by diagnostic status were suicide: 0.78 ± 0.22, control: 0.60 ± 0.11, depression: 0.82 ± 0.25, Alzheimer’s: 1.20 ± 0.32).