The exact role of SIRT1 in cancer is presently not well understood: SIRT1 was found to deacetylate a number of proteins downstream of MYC, P53, HIF, TGF-β, and WNT signaling, and acts as a tumor suppressor or a tumor-promoting factor, depending on the specific biological context [54]. Here, TGFB1 is linked to neoplasm.