The 11 upregulated genes (ARID5A, CDC42EP3, CDKN1A, FLT3, JUNB, MAP2K3, MYBPC2, RGS14, RNASEK, TBC1D30, and TXNDC11) in the high-risk group were recognized as putative biomarkers of TMZ resistance in the tumor mass of patients with primary GBM. The gene discussed is CDKN1A; the disease is glioblastoma.