These ligands are added to the surface of NPs, enabling the optimal coupling of the nanocarrier PS conjugates to overexpress cancer surface recognition molecules, such as epidermal growth factor receptors (EGFR), folate receptors (FR), transferrin receptors (TfR), CD44, and CD133, to improve PS subcellular internalization and accumulation [96,97,98]. This evidence concerns the gene CD44 and cancer.