In fact, in the RP-mimicking retina degeneration induced in rats by N-methyl-N-nitrosourea (MNU), the Mϋller glia enhanced the secretion of Cx3cl1 cytokine, which induced an increase in Cx3cl1 levels in microglia and triggered their migration to the outer retina [57]. This evidence concerns the gene CX3CL1 and retinal degeneration.