HPGD and intrahepatic cholangiocarcinoma: In fact, our study showed that GelMA ICC could slightly increase PGE2 levels in the BMSCs and co-treatment with GelMA ICC and SW033291 could significantly induce BMSCs to produce more PGE2 than GelMA ICC alone, suggesting the PGE2 release of BMSCs was majorly attributed to the action of small molecule inhibitor of 15-PGDH (SW033291) (Figure 5G).