TLR4 and neoplasm: Examples of the importance of such targeted co-delivery can be found in the context of anti-cancer vaccines, where studies have demonstrated that untargeted delivery of NA-based adjuvants, such as TLR4 and CD40 encoding mRNA, caused an enhancement in tumor resistance to tumor-specific cytotoxic T cells and neoangiogenesis, respectively [26,27]; while the precise ex-vivo electroporation of these exact adjuvants into immunosuppressed tumor-infiltrating DCs restored their antigen-presenting potential to promising results [28,29].