Δ9-THCA activated PPARγ and increased mitochondrial mass in neuroblastoma N2a cells and prevented cytotoxicity induced by serum deprivation in STHdh Q111/Q111 cells and by mutHtt-q94 in N2a cells. Δ9-THCA showed potent neuroprotective activity, worthconsideration for the treatment of Huntington’s disease and possibly other neurodegenerative and neuroinflammatory diseases. This evidence concerns the gene PPARG and Huntington disease.