HTR1A and depressive disorder: This study showed that acute systemic administration of cannabidiol increases extracellular serotonin levels through activation of 5HT1A and CB1 in the ventromedial prefrontal cortex, involved in the regulation of emotional impairment, as cannabidiol may be proposed as a potential drug with therapeutic indications for the treatment of depressive disorders associated with chronic neuropathic pain [83].