GPR55 and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: The acidic form of CBD was studied for its anticonvulsant effect in a mouse model of Dravet syndrome, and it was found that CBDA exhibited significant anticonvulsant properties through a mechanism that could involve the 5-HT1A, GPR55, or TRPV1 receptors [136].