Most importantly, using CT26 and MC28 bilateral tumor models, they showed that PD-L1 blockade had a synergistic abscopal effect with NCP@pyrolipid-based PDT, meaning that the combination therapy induced the regression of the primary tumors (right, irradiated tumor) and the distant tumors (left, unirradiated tumor), together with an increased infiltration of both primary and distant tumors with CD8+ T cells, while it increased infiltration of distant tumors only with CD45+ leukocytes and CD4+ T cells. Here, CD4 is linked to neoplasm.