W-TPB nMOFs were found to have a potent antitumor activity in vivo on lymphoblastoid TUBO cells, where PDT induced a significant tumor regression, accompanied by the induction of tumor infiltration by macrophages and DCs, the maturation of DCs, and an increase in systemic levels of inflammatory cytokines (IFN-α and IL-6). This evidence concerns the gene IFNA1 and neoplasm.