TGFB1 and neoplasm: Moreover, these NPs suppress the expression of cancer cell stemness (OCT4, Nanog, SOX2) and pro-angiogenic (TGF-β, sonic hedgehog and vascular endothelial growth factor) genes, and potentiate the anti-tumor immunity by favoring the switch of TAMs toward M1 and increasing cytotoxic CD8+ T cells, while reducing regulatory T cell levels.