FERR (i.e., NOX4-mediated H2O2 and lipid peroxides increment) and apoptosis (i.e., caspase 3 activation and Bax upregulation as well as Bcl-2 downregulation) induction have been observed in mammary mouse 4T1 tumor cells and human A375 melanoma cells treated with ACC@DOX–CaSi–PAMAM-FA/mPEG. Here, BAX is linked to neoplasm.