SUMO1 and Alzheimer disease: It is significant that the KED vasoprotective peptide [60], which has a neuroprotective effect in models of Alzheimer’s disease in mice in vitro and in vivo [61,62], regulated the mRNA involved in expression of the cell senescence and apoptosis genes (p16, p21), of neurogenesis (NES, GAP43), and of other genes involved in the pathogenesis of Alzheimer’s disease (SUMO1, APOE, IGF1) [22].