NES and early-onset autosomal dominant Alzheimer disease: In a recent study, it was demonstrated, using molecular dynamics methods, that the neuroprotective peptide EDR interacts with a dsDNA sequence that has been identified in the promoter regions of genes involved in the pathogenesis of Alzheimer’s disease (CASP3, TP53, SOD2, GPX1, PPARA, PPARG, NES, GAP43, SUMO1, APOE, and IGF1) [61].