YY1 and nonpapillary renal cell carcinoma: In summary, our study demonstrated that LINC02532 knockdown potentiates the radiosensitivity of ccRCC cells in vitro and in vivo through the miR-654-5p/YY1 axis, providing insights into the role and molecular mechanism of LINC02532 in regulating ccRCC tumorigenesis and radioresistance.