In other words, several possibilities could be pointed out for future treatment of COVID-19, including (1) the use of stimulators or agonists of the protective pathway components to favor their function, such as an ACE2 protein-based vaccine or a recombinant ACE2, AT2R or MasR stimulator, or (2) the use of inhibitors targeting the Ang II/AT1R axis, such as AT1R blockers or Ang II antagonists. Here, ACE2 is linked to COVID-19.