SIRT3 and Myocardial fibrosis: Moreover, resveratrol can influence the occurrence and progression of myocardial fibrosis by activating Sirtuin 3 (SIRT3), regulating the levels of hydroxyproline (Hyp), type I collagen gels (COL1), type IIIcollagen gels (COL3) and the expression of TGF- β, or by regulating the levels of SDF-1 and immune cytokines such as malondialdehyde (MDA), TNF-α, and IL-1 in oxidative stress [24].