Similar to our results, the antitumor effect of nifuroxazide was previously reported in several mouse tumor models including mice bearing A375 melanoma tumors [21], a cancer colon model (CT26 bearing mice) [54], and an orthotopically-implanted hepatocellular carcinoma model [55]; these studies indicated that the antineoplastic effects of nifuroxazide are mediated via inhibiting the STAT3 activity. Here, STAT3 is linked to hepatocellular carcinoma.