One proposed mechanism of CUR ameliorating DM is related to its antihyperlipidemic activity via suppression of fatty-acid synthase, carnitine palmitoyltransferase 1, 3-hydroxy-3-methyl glutaryl coenzyme A reductase, and acyl-CoA cholesterol acyltransferase enzymes [114]. The gene discussed is FASN; the disease is diabetes mellitus.