Further, the results of the current research are supported by various studies on epilepsy demonstrating the increased levels of pro-inflammatory mediators (IL-1 beta, IL-6, TNF alpha, and NF-kB) representing neuroinflammation in epileptic-brain-mediated generation of secondary seizures, which indicates the severity of seizures [41,42,43,44]. This evidence concerns the gene TNF and epilepsy.