In support of the above report, chondroitin sulfate tends to be an effective approach in epilepsy as our data revealed that subsequent treatment with chondroitin sulfate significantly (p < 0.05) and dose-dependently (100 & 200 mg/kg; p.o.)reinstated the endogenous antioxidant levels (glutathione, catalase, and superoxide dismutase (SOD)) and decreased the level of TBARS in brain tissue, indicating the reduction in oxidative stress as compared to the PTZ- and pilocarpine-induced diseased groups’ brain tissue. This evidence concerns the gene SOD1 and epilepsy.