The administration of PTZ at a subconvulsive dose of 40 mg/kg (i.p.)for 15 days, on alternative days, precipitated status epilepticus in mice as reflected by a statistically significant increase (p < 0.01) in the increased level of TBARS and decreased levels of catalase, glutathione, and superoxide dismutase (SOD), representing the oxidative stress in mice when compared to that of the vehicle-treated control groups. This evidence concerns the gene CAT and status epilepticus.