The antioxidant effect of chondroitin sulfate in epilepsy has been identified by studying the various biochemical oxidative stress parameters indicating the prolonged seizure-induced oxidative stress in epilepsy in terms of the levels of TBARS (a byproduct of lipid peroxidation that gets elevated under particular pathology indicating the brain oxidative stress tissue injury due to prolonged repetitive seizures), catalase, glutathione, and superoxide dismutase (SOD), representing brain tissue injury. Here, CAT is linked to epilepsy.