VEGFR-3 is one of the most used markers for lymphatic endothelial cells in breast cancer tissues, but there are also other proteins reported to be specific for lymphatic vessels such as podoplanin, lymphatic vessel endothelial hyaluronic acid receptor-1 (LYVE-1), and prospero-related homeobox-1 (PROX-1) [96,97]. This evidence concerns the gene PROX1 and breast cancer.