Indeed, the methylation pattern of the human deafness, autosomal dominant 5 gene at chromosome 7p15 (DFNA5) increased the risk of lymph node metastasis [101], whereas the hypermethylation of the tumour suppressor gene CDH1, which encodes for the transmembrane glycoprotein E-cadherin, increased the axillary lymph node metastasis with worse disease-free survival of these patients [102]. The gene discussed is CDH1; the disease is deafness.