SOX5 and atrial fibrillation: However, as the protective A allele of the rs11047543 (SOX5) SNV and the protective T allele of the rs2106261 (ZFHX3) SNV reached the risk of recurrence threshold of p < 0.1 and were consequently flipped, it was subsequently found that a higher PRS was indeed associated with a higher chance of AF recurring after DCC treatment (OR = 4.174, 95% CI = 1.454–11.980).