-single cells exhibit a range of secretory phenotypes for CXCL1, CXCL5, and CXCL8-secretions of ELR+ CXC chemokines were found from thousands of single CRC and stromal cells-CRC and stromal cells exhibit polyfunctional heterogeneity in the combinations and magnitudes of secretions for these chemokines-discordances exist between secretory states measured and gene expression for these chemokines among single cells. This evidence concerns the gene CXCL5 and colorectal carcinoma.