New driver mutations were identified that developed during the evolution of both adenoma and cancer: on one hand OR1B1 (GPCR signaling pathway) was related to adenoma evolution; on the other hand, LAMA1 (PI3K-Akt signaling pathway) and ADCY3 (FGFR signaling pathway) had a role in CRC evolution. This evidence concerns the gene PIK3CA and adenoma.