A study that included 330 subjects and used magnetic resonance spectroscopy as a diagnostic method proved that carriers of the G allele presented a significantly higher hepatic fat content compared to individuals homozygous for the C allele [31].This study suggested that adiponutrin could be a keyfactor in understanding the mechanisms involved in the differentiation of benign fatty liver and fatty liver with metabolic consequences. The gene discussed is PNPLA3; the disease is fatty liver disease.