The objective of this study isto assess the relation between PNPLA3 genotypes and the degree of hepatic fatty loading in subjects with type 2 diabetes mellitus, as well as with the degree of subclinical atherosclerosis and components of metabolic syndrome, and study the connection with the cardiovascular risk of this gene, viewed in the last few years as a marker of sensitivity regarding hepatic disease. This evidence concerns the gene PNPLA3 and liver disorder.