The association between PNPLA3 and steatosis has been observed in seven out of eight genomic studies [19] and in many other studies that included Chinese and African American subjects, participants of the third National Health and Nutrition Examination Survey (NHANES) study [20], children with NAFLD and patients with morbid obesity [21,22]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.