BT5528 is a Bicycle Toxin Conjugate (BTC), consisting of a bicyclic peptide targeting this tumor antigen EphA2 overexpressed in different tumors such as non-small-cell lung cancer (NSCLC), ovarian cancer, triple-negative breast cancer (TNBC), gastric/upper gastrointestinal (GI), pancreatic and urothelial cancers, and linked to a cytotoxin (monomethyl auristatin E [MMAE]) through a tumor microenvironment cleavable Val-Cit linker. The gene discussed is EPHA2; the disease is non-small cell lung carcinoma.