In addition, a previous study by Olsen et al. [70] revealed that Ang-4 inhibits angiogenesis and constrains the increased interstitial fluid pressure that is generated by bFGF (basic fibroblast growth factor) and VEGF in the human small-cell lung cancer (SCLC) cell line, GLC19.The impact of Ang-4 on lung cancer development is not well-established. This evidence concerns the gene ANGPT4 and lung cancer.