VWF and Thrombocytopenia: The diagnosis of venous combined micro-macrothrombosis can be established with the laboratory findings of (1) thrombocytopenia; (2) overexpressed ULVWF/VWF antigen or activity; (3) increased activity of FVIII; (4) markedly increased D-dimers; and (5) increased thrombomodulin [65], as shown in Table 4.