In 2008, the attention of the scientific community on patatin-like phospholipase domain-containing 3 (PNPLA3) increased due to a cohort-type study that reported a close correlation between a genetic variant of PNPLA3, rs738409 C>G, and an increased risk of developing hepatic steatosis and inflammation. Here, PNPLA3 is linked to Hepatic steatosis.