CXCR4 and neoplasm: Preclinical studies with fractionated standard radiation therapy and simultaneous weekly administration of cisplatin plus the CXCR4 inhibitor Plerixafor (AMD3100) in xenografts from patients with orthotopic cervical cancer showed an improved response of the primary tumor and a reduced number of lymph node metastases without an increase in the early- or late-stage of side effects [76].