In addition to driver mutation KIT D816V, somatic mutations in SRF2, ASXL1, RUNX1, TET2, CBL, K/N-RAS, and EZH2 have been identified in MCL patients, explaining, at least in part, the more aggressive course and poorer survival of MCL compared to other SM variant [40]. The gene discussed is ASXL1; the disease is mantle cell lymphoma.