PRMT2 and breast cancer: In humans, in addition to the full-length PRMT2 expressed from a gene of eleven exons [5], six alternatively spliced PRMT2 isoforms have been detected (UniProtKB–P55345) and four of them (PRMT2L2, PRMT2α, β, and γ) have been isolated from breast cancer cells [13,14] (Figure 3).