BDNF is reported to slow the progression of motor neuron atrophy in an animal model of amyotrophic lateral sclerosis (ALS) [126], and the TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) improved motor neuron deficits in the superoxide dismutase 1 (SOD1G93A) ALS mouse models [127]. The gene discussed is BDNF; the disease is amyotrophic lateral sclerosis.