Some studies support our results, showing that increased expression of autotaxin in PCa cell lines is mediated by the downregulation of HDAC7 and HDAC3 [37]; additionally, HDAC5 is downregulated in human cancer, namely PCa [38], and decreased expression of HDAC4 increases the growth of PCa cells [39]. This evidence concerns the gene ENPP2 and posterior cortical atrophy.