PTEN and neoplasm: Indeed, simultaneously reduced PTEN and high PI3K/mTOR expressions were associated with lymphatic invasion (p = 0.01), advanced tumor stage (p = 0.01), distant metastases (p = 0.03), shorter DFI (p = 0.04), and shorter OS (p = 0.05) in univariate analysis (Table 5, Figure 4).