Pyridoxine-dependent seizures are a rare genetic disorder of vitamin B6 metabolism caused by pathogenic variants in ALDH7A1 (a member of subfamily 7 in the aldehyde dehydrogenase gene family), and is characterized by neonatal-onset seizures that are resistant to common anticonvulsants, but controlled by daily treatment with vitamin B6. The gene discussed is ALDH7A1; the disease is pyridoxine-dependent epilepsy.