During the early development, EGFR is highly expressed in the midbrain and hippocampus, and its increased expression has been also reported in many pathophysiologies, including Alzheimer’s, Huntington’s, Parkinson’s disease, amyotrophic lateral sclerosis, and traumatic brain injury associated with reactive gliosis [31]. The gene discussed is EGFR; the disease is amyotrophic lateral sclerosis.