PLAT and Stroke: Fenofibrate treatment during the acute phase of experimental stroke in rats by transient middle cerebral artery occlusion (MCAO) in combination with thrombolysis by tissue plasminogen activator (tPA) exerted a reduction in the infarction volume (total, cortical, and striatal areas) and increased expression of ICAM-1 (a marker of leukocyte/endothelium interactions) and CD11b (a marker of activated microglia) [53].