Our previous studies found that aberrant overexpression of NEDD4 in gastric cardia adenocarcinoma is correlated with the tumor invasion and metastasis [18] and NEDD4 mediates the EGFR lung cancer cell migration signaling through interacting with the EGFR signaling complex and promoting lysosomal secretion of cathepsin B [19]. The gene discussed is EGFR; the disease is gastric cardia adenocarcinoma.