Consequently, the modified activation of a plethora of transcription factors has similarly been noticed, inclusive of a reduced activation of PGC-1 alpha in α-synuclein-mutated A53T PD-induced pluripotent stem cells of a patient, specifically of transcription factor EB (TFEB), which regulates the autophagy–lysosomal pathway in rats with heightened α-synuclein expression via adeno-associated virus [165]. The gene discussed is SNCA; the disease is Parkinson disease.