SNCA and Parkinson disease: Consequently, since productive autophagic degradation depends on the proper enzymatic function of the lysosome, the activity of the lysosome in differing enzymes, such as cathepsin B, hexosaminidase, and Gcase, seems to decline in α-synuclein PD-induced pluripotent stem cells in comparison to control-induced pluripotent stem cells, potentially due to faulty endoplasmic reticulum to Golgi apparatus trafficking [156,160,161].