In turn, mild overexpression of OPA1 protects against cardiac and cerebral ischemia [113], while the metalloendopeptidase OMA1 (which is activated in response to stress and mediates OPA1 proteolytic processing) plays a central role in mediating ischemia-induced heart failure and cardiac hypertrophy [114]. The gene discussed is OPA1; the disease is Cerebral ischemia.