CANX and myeloid sarcoma: Recently, some authors have suggested that calnexin is involved in the transmigration of T lymphocytes within the CNS, showing the chaperon to be highly expressed in endothelial cells of the blood–brain barrier (BBB) of MS patients and demonstrating that knockout mice for calnexin are resistant to the induction of experimental autoimmune encephalomyelitis (EAE) (i.e., the MS animal model) [23].