Alternatively, it is possible that the massive NLRP3 expression observed in LPS+ Aβ42-stimulated PBMC of AD overrules the inhibitory effect of miR-223-3p on NLRP3 activation, as was previously observed in an in vitro model of endothelial cells that were stimulated with the recombinant proteins of Treponema pallidum [41]. The gene discussed is NLRP3; the disease is Alzheimer disease.