IL18 and Alzheimer disease: To summarize: (1) NLRP3 (p < 0.05) (Figure 1A); (2) ASC (p < 0.01) (Figure 1B); (3) IL-18 (p < 0.001) (Figure 1D); (4) IL-1β (p < 0.001) (Figure 1E) mRNA expression was significantly upregulated in AD compared to HC.