Similar results have been described by Xue et al. [61], who have suggested that the response of neuroblastoma cells that express functional p53 after DNA damage depends on the amount of damage and the cell type in question: at high doses of radiation, N-type IMR-32 cells undergo apoptosis rather than cell cycle stop, while S-type SH-EP cells experience senescence. This evidence concerns the gene TP53 and neuroblastoma.