miRNA appeared to be downregulated in neuroblastoma cell lines due to promoter methylation, but treatments with 5′azacitidine increased miRNA expression and led to malignancy decrease through downregulation of miRNAs’ targets such as CDK6, DNMT3B, E2F3, OLFM3, and IFNAR1. The gene discussed is CDK6; the disease is neuroblastoma.