In another interesting study employing a mouse model of intestinal ulcers, Yu et al. [152] administrated a probiotic strain of Escherichia coli fused with epidermal growth factor (EGF) in mice and observed increased wound healing of the epithelial layers and decreased disease severity when compared with controls, suggesting that the beneficial effects of probiotics could be further enhanced by the engineered addition of various growth factors. Here, EGF is linked to intestinal disorder.