APP and Alzheimer disease: Disease animal models recapitulating AD amyloidosis have been developed including transgenic APP/PS1, APP23, APPswe, J20, PS2APP, arcAβ, 5 × FAD, 3 × Tg mice, TgF344 and McGill-R-Thy1-APP rats [12,13,14,15,16,17,18,19], second-generation AppNL-G-F, Apphu/hu knock-in mice [20,21], third-generation mouse models [22,23], as well as non-human primate model [24].