Pyridine (6a–g), pyrimidine (10a–f), and cyclohexyl ester (13a–d, 15 and 17) analogues of CGA in hand, we evaluated their inhibitory activity of melanin formation in B16 melanoma cells under stimulus of α-MSH, and the IC50 values are summarized in Table 1 (see Supplementary Materials). This evidence concerns the gene STAMBP and melanoma.